She wishes to avoid endangering other people and relies on her powers to try to solve problems on her own, often times despite her better judgment. She often prefers to be solitary and dislikes the idea of being restricted by rules and duties such as those of Judgement and Anti-Skill. While generally amicable and humble, Misaka is highly individualistic. She can also be slightly hypocritical at times, getting angry at Touma for not calling her by her name despite never once calling him by his. She has a very irrational and unexplained fear of bugs, as shown in episode 6 of Toaru Kagaku no Railgun. When she realizes that a stuffed animal another person is carrying is just a regular frog, she immediately loses all of her interest in the stuffed animal. She likes frog merchandise, but only if it features Gekota. To add to this childishness, she has a soft spot towards cute things, most specifically, Gekota and Kill Bear merchandise, and is easily embarrassed. She often shows an incredibly immature and selfish side and displays heavy tsundere tendencies when her crush, Touma, insults her.

This is probably because she was originally a level 1 esper, and became a Level 5 esper through hard work. Despite this, she is friendly and easygoing, to the point where Saten Ruiko and Uiharu Kazari comment on how they are shocked to find that, compared to other Level 5's, she doesn't look down on lower-level espers at all.

In reality, she's short-tempered, prideful, has an improper attitude with some slightly violent, boyish tendencies (or masculine since she wears boxers and an undershirt), and insecurities, a fact few people know of. To most people, she is considered a 'proper lady' or ojou-sama ( お嬢様, ojou-sama ?).

Mikoto misaka honey select card